Progesterone-mediated oocyte maturation
| PAG Title | Progesterone-mediated oocyte maturation |
| PAG ID | WIG000597 |
| Type | P |
| Source Link |  MSigDB |
| Publication Reference | NA |
| PAG Description | Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP. |
| Species | Homo sapiens |
| nCoCo Score | 2,850 |
| Base PAG ID | WIG000597 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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